58yo female with hyperpigmented papules on arms and palms

Presenter: Olga Demidova, DO; Laura Jordan, DO; Cole Cahill, DO; Schield Wikas, DO; Monte Fox, DO
Dermatology Program: Tri-County Dermatology
Program Director: Schield Wikas, DO
Submitted on: Nov 5, 2016

CHIEF COMPLAINT:  A 58-year-old female presented to the dermatology clinic with complaints of asymptomatic hyperpigmented papules over arms and palms.

CLINICAL HISTORY:

Signs and symptoms:  A 58-year-old female was referred to the dermatology clinic by her primary care physician for evaluation of asymptomatic hyperpigmented papules involving her arms and palms. Growths appeared several weeks prior to the initial visit. During the visit, the patient reported mild shortness of breath that is chronic for her and may have worsened in the past few weeks. She denied changes in medications and any recent illness.

Previous Treatment:  N/A

Other information:  Her past medical history consisted of asthma, COPD, GERD, atrial fibrillation, breast cancer, hypertension, hypothyroidism, infantile seizures, and radiation treatments. Past surgical history included breast lumpectomy, breast biopsy, cholecystectomy, and hysterectomy. Patient denied any personal or family history of skin disease or skin cancer. Her medications at the time included atenolol, levothyroxine, flomax, hydrochlorothiazide, ibuprofen, and probiotics, and she admitted allergies to adhesive tape, voltaren, dolobid, vicodin, calan, lipitor, crestor, zetia, and simvastatin. Patient was a former cigarette smoker and denied alcohol use.

PHYSICAL EXAM:

Well-nourished female in no acute distress. Skin exam revealed hyperpigmented non-tender, freely mobile papules over extensor surfaces of the arms and palms (Figs. 1,2).

 

LABORATORY TESTS:

N/A

DERMATOHISTOPATHOLOGY:

Biopsy was obtained from the left lateral forearm and revealed deep dermal inflammatory infiltrate comprised of well-organized granulomas embedded in a dense fibrotic stroma with admixed lymphocytic inflammation. This subcutaneous granulomatous dermatitis was consistent with sarcoidosis.

DIFFERENTIAL DIAGNOSIS:

1.   Subcutaneous sarcoidosis
2.   Psoriasis
3.   Mycobacterial infection


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