Violaceous nodule of the upper extremity

Presenter: Helen Kaporis, D.O.
Dermatology Program: KCOM- Texas Division
Program Director: Dr Bill Way
Submitted on: Mar 4, 2011

CHIEF COMPLAINT:  Nodule of 6 months duration


Signs and symptoms:  Asymptomatic

Previous Treatment:  None


2 cm violaceous nodule of the left upper extremity


Violaceous nodule left arm


Violaceous nodule



Diffuse nodular proliferation of markedly enlarged atypical lymphocytes involving dermis and subcutaneous adipose tissue. The monomorphic population showed large nuclei and prominent nucleoli with scant cytoplasm. Abundant mitotic figures and pleomorphism was also noted. Epidermotropism was not observed. Immunohistochemical stains were positive for CD20, PAX5, and diffusely with BCL-2, as well as BCL-6, CD-79a, and slightly for CD10. Ki-67 immunostain highlighted a large percentage of the tumor cells. A final diagnosis of diffuse large B-cell lymphoma was made.


Diffuse Large B Cell Lymphoma 20x


Diffuse Large B Cell Lymphoma 200x


Immunohistochemical Stain CD 20


1.   Basal Cell Carcinoma
2.   Kaposi’s Sarcoma
3.   Lymphoma
4.   Leishmaniasis

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