Presenter: Helen Kaporis, D.O.
Dermatology Program: KCOM- Texas Division
Program Director: Dr Bill Way
Submitted on: Mar 4, 2011
CHIEF COMPLAINT: Nodule of 6 months duration
Signs and symptoms: Asymptomatic
Previous Treatment: None
2 cm violaceous nodule of the left upper extremity
Diffuse nodular proliferation of markedly enlarged atypical lymphocytes involving dermis and subcutaneous adipose tissue. The monomorphic population showed large nuclei and prominent nucleoli with scant cytoplasm. Abundant mitotic figures and pleomorphism was also noted. Epidermotropism was not observed. Immunohistochemical stains were positive for CD20, PAX5, and diffusely with BCL-2, as well as BCL-6, CD-79a, and slightly for CD10. Ki-67 immunostain highlighted a large percentage of the tumor cells. A final diagnosis of diffuse large B-cell lymphoma was made.
1. Basal Cell Carcinoma
2. Kaposi’s Sarcoma